Characteristics of immunologic homeostasis in the late period after reconstructive operations on the heart valves
Liudinovskova, R.A.; Gromova, G.V.; Tsygankova, S.T.; Tarichko, I.V.; Ivanov, V.A.; Buniatian, K.A.; Akimova, N.I.; Tokareva, L.V.
Vestnik Akademii Meditsinskikh Nauk SSSR 10: 26-28
1990
ISSN/ISBN: 0002-3027 PMID: 2278178 Document Number: 359764
The immune status, i.e. T and B lymphocytes and their populations, was assessed after heart valve replacement or reconstruction in 70 patients with acquired heart defects. In 30%, the immune status was found to be normal which corresponded to inactive rheumatic process in these patients; 40% showed activated immunity manifested by increased T-active, T-total, T-helper, and T-suppressor numbers compared to the first group, which corresponded to activation of a rheumatic process in these patients. The rest 30% patients showed suppressed immunity, i.e. diminished subpopulations of T lymphocytes and B lymphocytes. These changes were detected in patients with circulatory insufficiency and progressive septic endocarditis. This allows for a conclusion that determination of the status of immunity and its correction are essential for cardiac surgery patients.