The concentrations of soluble vascular cell adhesion molecule-1 and lipids are independently associated with venous thromboembolism
González-Ordóñez, A.José.; Fernández-Carreira, Jé-Manuel.; Fernández-Alvarez, C.Rosa.; Venta Obaya, R.; Macías-Robles, Mìa.Dolores.; González-Franco, A.; Arias Garcìa, M.Ana.
Haematologica 88(9): 1035-1043
2003
ISSN/ISBN: 0390-6078 PMID: 12969812 Document Number: 565417
Background and Objectives. Venous thromboembolism (VTE) involves inflammation and a relation with dyslipidemia which remains controversial. The vascular cell adhesion molecule-1 (VCAM-1) is a ligand expressed by activated endothelium (and recruits leukocytes) whose soluble form (sVCAM-1) increases in atherosclerosis, severe hypertriglyceridemia or deep vein thrombosis (DVT) in acute phase. We analyzed the association between VTE (> 6 months after), sVCAM-1 and lipid concentrations. Design and Methods. Case-control study involving 126 consecutive patients (aged 25-80 years, 49% males) and 125 controls of similar age and gender. Results. The patients had a more unfavorable lipid profile than controls (higher triglycerides (p<0.001), LDLc/HDLc ratio (p<0.01) or total cholesterol (TC) (p=0.07)) and higher sVCAM-1 concentration (p<0.01) even adjusting for arterial diseases. VTE was associated with extreme values of TC, LDL-c, triglycerides (>P90) and HDL-c (