Efficacy of vitamin E, phosphatidyl choline and pyruvate on Abeta neurotoxicity in culture
Shea, T.B.; Ekinci, F.J.; Ortiz, D.; Wilson, T.O.; Nicolosi, R.J.
Journal of Nutrition Health and Aging 7(4): 252-255
2003
ISSN/ISBN: 1279-7707 PMID: 12917750 Document Number: 563654
Oxidative stress is a pivotal factor in neuronal degeneration including that induced by exposure to amyloid-beta (Abeta). Treatment with antioxidants such as vitamin E can alleviate Abeta neurotoxicity. However, vitamin E was only marginally effective in clinical trials in Alzheimer's disease. Recent studies indicate that treatment with vitamin E (as a-tocopherol), sodium pyruvate and phosphatidyl choline (PC) is more effective than vitamin E alone against neuronal oxidative stress. We demonstrate herein that treatment of cultured murine cortical neurons with these 3 agents is also more effective than vitamin E alone against Abeta neurotoxicity as assayed by generation of reactive oxygen species and increased levels of phospho-isoforms of the microtubule-associated protein tau. These data underscore the potential efficacy of a combinatorial neuroprotective formulation against Abeta neurotoxicity.