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D-limonene induces apoptosis of gastric cancer cells

Lu, X-guang.; Feng, B-an.; Zhan, L-bin.; Yu, Z-hong.

Zhonghua Zhong Liu Za Zhi 25(4): 325-327

2003

ISSN/ISBN: 0253-3766
PMID: 12921557
Document Number: 562618
Objective: To investigate the apoptosis effect induced by D-limonene on BGC-823 gastric cancer cells. Methods: The expression of p53, bcl-2 in BGC-823 cells and qualitative, quantitative index of cell apoptosis were detected with MTT, electron microscopy, flow cytometry and immunohistochemical method. Results: D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells. Conclusion: D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.

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