Molecular-biological markers as prognostic factors in breast cancer of I-IIA stage
Stepanova, E.V.; Zagrekova, E.I.; Ermilova, V.D.; Turbin, A.D.; Petrovichev, N.N.; Vysotskaia, I.V.; Dbar, Z.N.; Pashchenko, N.V.; Baryshnikov, A.I.; Lichinitser, M.R.
Arkhiv Patologii 65(3): 14-18
2003
ISSN/ISBN: 0004-1955 PMID: 12879604 Document Number: 560192
The study of molecular-biological markers for prediction of recurrence-free survival in breast cancer stage I-IIA demonstrates that high expression of thymidilate synthetase and high maximal density of microvessels are prognostically effective and that the prognosis is influenced by expression of both Bcl-2 and Bax. Low recurrence-free survival was observed in Bcl-2-/Bax patients (31%, median 44 months) while such survival was high in Bcl-2+/Bax patients (86%, median was not reached). The findings can be used for prognostication of a breast cancer clinical course.