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The influence of surgical intervention on the functional status of hypophyseal-thyroid system in patients with acute destructive appendicitis

Gordienko, A.I.

Klinichna Khirurhiia 8: 25-29

2003

ISSN/ISBN: 0023-2130
PMID: 14610789
Document Number: 559854
The changes of thyrotropin (TSG), thyroxin (T4) and triiodothyronine (T3) blood levels in patients with acute destructive appendicitis and initial decrease of T3, as well as its absorption of T4 by lymphocytes after operation were studied. It is established that "low T3 level syndrome" in surgical patients exceeds the limit of quantitative assessment of the level of thyroid hormones' concentration in peripheral blood. It includes also damage of functional intersystem (endocrine-immune) links. Hormone replacement therapy using thyroid hormones in order to activate immunocytes indirectly (through thymic factors) in patients with acute destructive appendicitis and initial decrease of T3 level and decreased activity of T-part of immunity is pathophysiologically justified.

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