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Functional state of the hypothalamo-hypophyseal-gonadal system in patients with chronic alcoholic intoxication

Kolupaev, G.P.; Iakovlev, V.A.

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 87(11): 1723-1725

1987

ISSN/ISBN: 0044-4588
PMID: 3434080
Document Number: 301575
The function of the hypothalamo-pituitary-gonadal system has been studied in 118 males with different stages of alcoholism. Comparison with the control group has shown decreased levels of interstitial cell stimulating hormone (ICSH), follicle-stimulating hormone (FSH), and testosterone, and elevated concentrations of prolactin (Prl). Differences in the parameters of hormonal activity expressed in a varying degree of a decrease in FSH, ICSH, and testosterone, and a Prl elevation are related to change in mutual regulatory influences between the gonads and hypothalamo-pituitary complex. The most informative parameters were concentrations of Prl and testosterone (considering elevation in the former and reduction in the latter hormone) and the ratio of their concentrations. Difference of these parameters in each group (corresponding to the stages of alcoholism) may be used as an additional diagnostic criterion of chronic alcohol intoxication.

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