Genetic analysis of wild measles virus strains isolated in the european part of the Russian Federation
Zhuravleva, I.N.; Lugovtsev, V.I.; Voronina, O.L.; Shilov, I.A.; Vaniusheva, O.V.; Lunin, V.G.; Naumova, M.A.; Mamaeva, T.A.; Tikhonova, N.T.
Voprosy Virusologii 48(4): 29-35
2003
ISSN/ISBN: 0507-4088 PMID: 12945204 Document Number: 559432
Eleven wild measles virus isolated, in 1988 and in 1999-2001 in the European territory of the Russian Federation, were investigated. On the basis of an analysis of N-gene region sequences, encoding the COOH terminal end of nucleoprotein, the isolates were divided into 2 subgroups. According to the WHO classification, subgroup 1 was in line with genotype A and subgroup 2--with genotype D. Subgroup 2 was close to genotype D4 but differed from it according to its composition of nucleotides on the average by 2.8%, and according to its amino-acid composition--by 2.6%. with respect to the WHO criteria, the latter can be referred to preliminarily as an independent genotype. Finally, the measles viruses' strains of genetic groups A and D circulated in the Russian Federation in 1988, and in 1999-2001.