Identification of the horizontal gene transfer based on phylogenetic data
V'iugin, V.V.; Gel'fand, M.S.; Liubetskiĭ, V.A.
Molekuliarnaia Biologiia 37(4): 674-687
2003
ISSN/ISBN: 0026-8984 PMID: 12942641 Document Number: 559318
We suggest a new procedure to search for the genes with horizontal transfer events in their evolutionary history. The search is based on analysis of topology difference between the phylogenetic trees of gene (protein) groups and the corresponding phylogenetic species trees. Numeric values are introduced to measure the discrepancy between the trees. This approach was applied to analyze 40 prokaryotic genomes classified into 132 classes of orthologs. This resulted in a list of the candidate genes for which the hypothesis of horizontal transfer in evolution looks true.