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FasL and Bax genes are differentially expressed in acinar epithelium and inflammatory cells of primary Sjögren salivary glands

Badillo-Almaraz, I.; Avalos-Díaz, E.; Villalobos-Hurtado, R.; Herrera-Esparza, R.

Minerva Medica 94(5): 341-345

2003

ISSN/ISBN: 0026-4806
PMID: 14973428
Document Number: 558298
Assess the expression of FasL, Bax, TNFa and IL-6, genes in salivary glands of primary Sjögren patients. Twenty minor salivary glands from patients with primary Sjögren syndrome were studied by in situ hybridization with cDNA fluorescent probes. An equal number of control biopsies were included. Sjögren salivary glands differentially display the inflammatory cytokines and pro-apoptotic mRNAs as follows: mononuclear infiltrating cells exhibited IL-6 and TNFa, whereas the ductal epithelium and acinary cells mainly expressed FasL and Bax. Control biopsies were negative. Present data suggest that local production of inflammatory cytokines would induce the Fas and Bax pathways committing the ductal epithelium and the acinary cells to apoptosis.

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Babaeva, A.G.; Skatkov, M.E. 1972: Radioautographic study of the mitotic cycle of the acinar epithelium of mouse salivary glands Biulleten' Eksperimental'noi Biologii i Meditsiny 73(5): 110-112
Gutkin, V.I.; Sviadoshch, E.A. 1970: Membrane potential of acinar cells of cat submaxillary salivary glands Biofizika 15(5): 857-862
Li, H.-b.; Zhang, F.-c.; Zhang, X.; Gan, X.-d.; Shi, Y.-p.; Bai, Y.-n.; Tang, F.-l. 2010: Expression of SSA antigen epitopes in minor salivary glands from patients with primary Sjögren's syndrome Zhonghua Yi Xue Za Zhi 90(17): 1187-1191
Sahin, A.; Vercamer, C.; Kaminski, A.; Fuchs, T.; Florin, A.; Hahne, J.C.; Mattot, V.; Pourtier-Manzanedo, A.; Pietsch, T.; Fafeur, V.ér.; Wernert, N. 2009: Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes International Journal of Oncology 34(2): 377-389
Wang, S.-q.; Ni, H.; Cheng, H.; Wang, G.-l.; Wang, T.-s.; Chen, L. 2004: Detection of differentially expressed genes in hepatocellularcarcinoma cells SMMC-7721 treated with Typhonium giganteum extract by mRNA differential display Zhongguo Zhong Yao Za Zhi 29(10): 974-977
Lane, H.C.; Callihan, T.R.; Jaffe, E.S.; Fauci, A.S.; Moutsopoulos, H.M. 1983: Presence of intracytoplasmic IgG in the lymphocytic infiltrates of the minor salivary glands of patients with primary Sjögren's syndrome Clinical and Experimental Rheumatology 1(3): 237-239
Skopouli, F.N.; Li, L.; Boumba, D.; Stefanaki, S.; Hanel, K.; Moutsopoulos, H.M.; Krilis, S.A. 1998: Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjögren's syndrome Clinical and Experimental Rheumatology 16(1): 63-65
Norman, J.E. 1997: Biopsy of labial salivary glands and lacrimal glands in the diagnosis of Sjögren's syndrome Journal of Rheumatology 24(2): 409
Mao, X.-M.; Xing, R.-W.; Jing, X.-W.; Zhou, Q.-Z.; Yu, Q.-F.; Guo, W.-B.; Wu, X.-Q.; Chu, Q.-J.; Feng, C.-Q. 2011: Differentially expressed genes in asthenospermia: a bioinformatics-based study Zhonghua Nan Ke Xue 17(8): 694-698
Ye, Y.-k.; Mi, Q.-w.; Luo, J.-x.; Meng, X.-j.; He, H.-c.; Wu, Y.-d.; Zhong, W.-d. 2015: Ten significantly differentially expressed genes in prostate cancer: Screening and verification Zhonghua Nan Ke Xue 21(5): 408-413
Komori, T.; Takemasa, I.; Higuchi, H.; Yamasaki, M.; Ikeda, M.; Yamamoto, H.; Ohue, M.; Nakamori, S.; Sekimoto, M.; Matsubara, K.; Monden, M. 2004: Identification of differentially expressed genes involved in colorectal carcinogenesis using a cDNA microarray Journal of Experimental and Clinical Cancer Research: Cr 23(3): 521-527
Yang, M.; Loda, M.; Sytkowski, A.J. 1998: Identification of genes expressed differentially by LNCaP or PC-3 prostate cancer cell lines Cancer Research 58(16): 3732-3735
Tan, Y-hong.; Yang, C-zheng.; Zhao, C-hua.; Qi, J.; Peng, H.; Wang, J-xiang.; Zhou, Y.; Xiao, Y.; Lan, L. 2004: Identification of differentially expressed genes involved in multidrug resistance in K562/A02 by cDNA microarray Zhonghua Zhong Liu Za Zhi 26(6): 328-332
Knowles, H.J.; Phillips, R.M. 2001: Identification of differentially expressed genes in experimental models of the tumor microenvironment using differential display Anticancer Research 21(4a): 2305-2311
Zhang, Q.; Zhang, Z.; Xin, D.; Na, Y.; Guo, Y. 2001: Suppression subtractive hybridization for identifying differentially expressed genes in renal cell carcinoma Chinese Medical Journal 114(8): 807-812
Zhao, Z.-W.; Bi, Y.-Y.; Zhang, H.-X.; Mao, Z.-F.; Chen, X.-H.; Ma, Q. 2005: Detection of apoptosis genes differentially expressed in patients with different degrees of benzene poisoning by cDNA microarray Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23(4): 245-247
Sun, Z.; Wu, Y-tang.; Zhang, W-qi.; Wang, X.; Wang, Y-ming. 2006: Cloning, identification and tissue expression of novel genes differentially expressed in diabetic rats supplemented with zinc Wei Sheng Yan Jiu 35(6): 712-715
Song, Y.; Yang, J.; Liu, J.; Huang, S. 2014: Analysis of differentially expressed genes in placental tissues of early-onset severe preeclampsia patients Zhonghua Fu Chan Ke Za Zhi 49(7): 501-505
Zhang, J.-q.; Wang, Y.; Wang, T.; Du, Z.-y.; Xu, Y.-j.; Lu, Y.-l. 2004: Differentially expressed genes in human giant-cell lung cancer lines with different metastatic potentials Zhonghua Zhong Liu Za Zhi 26(10): 590-593
Shimizu, M.; Suzuki, K.; Fujii, N.; Takahashi, H. 2003: Identification of the cDNA of differentially expressed genes in the transition zone of cucumber seedlings by fluorescent differential display Uchu Seibutsu Kagaku 17(3): 232-233