Top Abstract Purchase Related
Home
>
Node
>
Subnode

Stereoselectivity in absorption of trans tramadol in rat intestine

Liu, H.-c.; Li, B.-x.; Dun, B.; Wang, Y.-l.

Yao Xue Xue Bao 38(12): 893-896

2003

ISSN/ISBN: 0513-4870
PMID: 15040078
Document Number: 558115
To investigate the stereoselectivity in absorption of trans tramadol (trans T) in rat intestine. The duodenum, jejunum and ileum were separately perfusated in situ with trans T dissolved in Krebs-Ringer buffer. Trans T enantiomers in the perfusate were analyzed with a high performance capillary electrophoresis (HPCE) method. The absorbed fractions of trans T enantiomers were similar among the different segments of the rat intestine. The absorbed fraction of (+)-trans T was lower than that of (-)-trans T when the concentration of trans T was not higher than 40 mumol.L-1. As the concentration of trans T increased, the absorbed fractions of trans T enantiomers were reduced and the difference in absorbed fractions between trans T enantiomers became not significant. Trans T enantiomers can be absorbed in different parts of the rat intestine. The intestinal absorption of trans T was stereoselective, (-)-trans T being preferentially absorbed.

Document emailed within 1 workday
Secure & encrypted payments

Jin, S-min.; Liu, H-chen. 2004: Gender-related differences in metabolism of the enantiomers of trans tramadol and trans O-demethyltramadol in rat liver microsomes Yao Xue Xue Bao 39(8): 581-585
Buraczewska, L. 1981: Absorption of amino acids in different parts of the small intestine in growing pigs. III. Absorption of constituents of protein hydrolysates Acta Physiologica Polonica 32(5): 569-584
Lepri, A.; Sia, S.; Catinelli, S.; Casali, R.; Novelli, G. 2006: Patient-controlled analgesia with tramadol versus tramadol plus ketorolac Minerva Anestesiologica 72(1-2): 59-67
Striebel, H.W.; Hackenberger, J. 1992: A comparison of a tramadol/metamizole infusion with the combination tramadol infusion plus ibuprofen suppositories for postoperative pain management following hysterectomy Der Anaesthesist 41(6): 354-360
Rindi, G. 1984: Thiamin absorption by small intestine Acta Vitaminologica et Enzymologica 6(1): 47-55
Kiriliuk, A.G.; Khmelevskiĭ YuV 1978: Mechanisms of interaction of vitamins B1 and PP during absorption in rat intestine Voprosy Meditsinskoi Khimii 24(1): 67-73
Sitnikova, V.P.; Lukankina, L.N. 1982: Absorption in the small intestine in children with pyelonephritis Pediatriia 5: 29-30
Luan, L.-b.; Zhao, N. 2006: The absorption characteristics of silybin in small intestine of rat Yao Xue Xue Bao 41(2): 138-141
Basova, N.A.; Mikelsone, V.I.; Tarvid, I.L.; Kushak, R.I.; Grigor'eva, V. 1992: Hydrolysis and absorption of lysozyme in the small intestine Voprosy Pitaniia 1: 56-60
Tsuji, A.; Nakashima, E.; Asano, T.; Nakashima, R.; Yamana, T. 1979: Saturable absorption of amino-cephalosporins by the rat intestine Journal of Pharmacy and Pharmacology 31(10): 718-720
Schickedanz, H.; Keil, E.; Freitag, S.; Bach, B. 1977: Intestinal absorption in children with resected small intestine Padiatrie und Grenzgebiete 16(3): 131-139
Horváth, K.; Bata, A.; Horn, G.; Simon, K.; Bodánszky, H. 1986: Expiratory H2 studies in absorption disorders of the small intestine Orvosi Hetilap 127(16): 945-947
Duret, R.L. 1972: Glucid absorption after massive small intestine resection Acta Gastro-Enterologica Belgica 35(5): 172-180
Abramzon, M.A.; Malkiel', R.I. 1973: Lipolytic activity of the small intestine and fat absorption in patients with arteriosclerosis Kardiologiia 13(10): 90-94
Mrozowski, D.; Parszewski, M.; Semanycz, J. 1972: Carbohydrate absorption following extensive experimental resection of the small intestine Patologia Polska 23(3): 383-385
Mattila, M.J.; Holsti, L.R.; Venho, V.M.; Takki, S. 1970: Absorption of drugs in vitro from the rat intestine damaged by triparanol or irradiation Arzneimittel-Forschung 20(4): 533-538
Yang, J-Xiang.; Gao, H-Wen.; Hu, Z-Jun.; Jiang, M-Hua. 2005: Sensitive determination of anionic surfactants in water with trans-4-[4'-(N-methyl-N-hydroxylethylamino)-cinnamyl-N-9-(4'-(2,2':6',2''-terpyridine))-phenylmethylene]pyridine bromide by the light-absorption ratio variation approach Journal - Association of Official Analytical Chemists 88(3): 866-872
Turk, D.E. 1972: Protozoan parasitic infections of the chick intestine and protein digestion and absorption Journal of Nutrition 102(9): 1217-1221
Hellier, M.D.; Holdsworth, C.D.; Thirumalai, C. 1971: The influence of amino acids on sodium and water absorption from the small intestine Gut 12(10): 854
Levin, A.A. 1974: Clinical significance of the disorders of hydrolysis and disaccharide absorption in the small intestine Klinicheskaia Meditsina 52(8): 33-37