Fermentative hydrolysate of mycelial waste of aminoglycoside antibiotics production as component of culture media used in biosynthesis of tobramycin
Cherkashina, N.V.; Litusov, N.V.; Mikhaĭlov, V.A.; Vasil'ev, P.G.; Rogozhin, A.Z.; Makhortov, V.L.; Bunakov, I.P.; Ustinova, N.B.; Andrus, E.A.
Antibiotiki i Khimioterapiia 48(10): 3-6
2003
ISSN/ISBN: 0235-2990 PMID: 15004972 Document Number: 557957
New nutrient media for cultivation of the tobramycin-producing organism were developed. As an additional source of nitrogen the media contain fermentative hydrolysate of the mycelial waste of manufacture of aminoglycoside antibiotics (tobramycin and apramycin). The use of the media provided a 20 to 50% decrease of consumption of soybean meal, an essential food raw material, and design of a low-waste technology for biosynthesis of tobramycin.