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Single nucleotide polymorphism and novel drug discovery

Kato, R.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 30(2): 303-308

2003

ISSN/ISBN: 0385-0684
PMID: 12610884
Document Number: 557406
The finding of genetic polymorphisms and clarification of the influences of their functions will be a possible way to obtain the therapeutic target moleculars for diseases. In clinical trial of new drug, which is targeted the therapeutic molecular, the gene examination will be needed to classify possible responder and unresponder patients. On the other hand, it is important to make effort on the elimination of candidate drugs, their pharmacokientic and metabolism, clinical efficacy and toxicity will be markedly influenced by genetic polymorphism.

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