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Single nucleotide polymorphism of +276 g > t adiponectin (APM1) gene in donors of Kharkiv population

Atramentova, L.A.; Poltorak, V.V.; Tyzhnenko, T.V.; Gorshunskaia, M.I.; Pocherniaev, A.K.

Tsitologiia i Genetika 44(6): 40-44

2010

ISSN/ISBN: 0564-3783
PMID: 21254618
Document Number: 645870
Polymorphism of adiponectine (APM1) gene in +276G > T position was studied. For this research we used blood samples of 103 donors (men/women: 65/38; 70 Ukrainian, 33 Russian) - habitants of Kharkiv. Frequencies of T and G alleles were pT = 0.55 and pG = 0.45 in a general group. They did not meaningfully differentiate either for men and women or for Russians and Ukrainians. Distribution of genotypes did not correspond to Hardy-Weinberg equilibrium: share of heterozygotes was 1.55 times higher than selectively-neutral value, share of TT homozygote is 0.55, and GG homozygote is 0.33 of equilibrium value.

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