Effect of thymostimulin on endocrine thymus function in thyroidectomized rats during suppressive hormone therapy
Hrinevych, I.I.; Bendiuh, H.D.; Ostapenko, O.M.
Fiziolohichnyi Zhurnal 49(6): 43-46
2003
ISSN/ISBN: 2522-9028 PMID: 14965037 Document Number: 557176
Due to disorders of hormonal balance in the organism, a decrease in thymic endocrine function occurred in rats after thyroidectomy. After removing the thyroid gland, we observed 1,3-2,2-fold decrease in the level of thymic hormone thymulin in the blood serum. When thyroxin was applied at a suppressive dose, endocrine function of the thymus did not restore. Injections of thymostimulin (Tp1) or its combination with thyroxin to thyroidectomized animals restored the level of thymulin up to the level in the intact rats due to effects of either injected preparation or induction of substances possessing thymosine-like activity.