Histological and immunohistochemical study of a neuroblastoma in a dog
Capucchio, M.T.; Lotti, D.; Cornaglia, E.; Valenza, F.; Schiffer, D.
Clinical Neuropathology 22(4): 176-179
2003
ISSN/ISBN: 0722-5091 PMID: 12908753 Document Number: 556912
A 13-year-old, male German Shepherd dog was euthanasized for a frontal temporal mass revealed by the MRI. The histological examination showed a proliferation composed of small round undifferentiated cells arranged in sheets or nests and sometimes in pseudorosettes interrupted by hypocellular zones of fibrovascular stroma. Immunohistochemical studies revealed the expression of neuroblastic epitopes. The presented neoplasm has many histological and immunohistochemical features in common with the group of olfactory neuroblastomas reported in man, so it could be classified as primitive neuroectodermal tumor with neuronal differentiation.