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Gene therapy for myocardial regeneration

Hayashi, S.-i.; Azuma, J.; Ogihara, T.; Morishita, R.

Nihon Rinsho. Japanese Journal of Clinical Medicine 61(5): 867-870

2003

ISSN/ISBN: 0047-1852
PMID: 12755017
Document Number: 555319
Most of cardiac myocytes have lost their ability to proliferate and differentiate into new myocytes. Therefore, myocyte regeneration and replacement in adult myocardium was thought to be impossible by medical community. However, recent findings in cardiovascular researches provide the possibility that gene therapy and stem cell therapy could have supportive effects on myocyte regeneration and myocardial revascularization in damaged heart. Here, we presented recent progress, especially, in gene therapy for myocardial regeneration under ischemic heart disease and heart failure.

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