Gene therapy of tumors of the head and neck: clinical use of the p53 tumor suppressor gene
Grgić, M.
Lijecnicki Vjesnik 122(1-2): 14-16
2000
ISSN/ISBN: 0024-3477 PMID: 10916351 Document Number: 519887
Gene therapy involves the introduction of genetic material (DNA) in patient cells, in order to produce therapeutic effect after expression of the new gene. New insights in head and neck tumor etiology and the development of genetic engineering techniques made the gene transfer a reality. This article gives a brief overview of investigations leading to clinical application of gene therapy in head and neck tumors. A good therapeutic response in more than 50% patients has been reported in literature. These results and future potential of gene therapy are discussed.