Thrombocytopenia caused by platelet destruction, consumption or abnormal pooling
Tamai, Y.; Takami, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 61(4): 581-586
2003
ISSN/ISBN: 0047-1852 PMID: 12718079 Document Number: 555105
In this article, we refer to thrombocytopenia caused by increased destruction/consumption of platelets(immune thrombocytopenia and non-immune thrombocytopenia), abnormal pooling, and dilutional loss. The cause of idiopathic thrombocytopenic purpura (ITP) is a accelerated platelet destruction due to autoimmune mechanism. Differential diagnosis is important between ITP and other thrombocytopenic disorders, because the treatment and prognosis are distinct. Drug-induced thrombocytopenia is the most common among secondary autoimmune thrombocytopenia and clinically important. The immediate cessation of all suspect drugs is necessary when drug-induced thrombocytopenia is suspected. Thrombocytopenia of disseminated intravascular coagulation(DIC) and thrombotic microangiopathy(TMA) occur in diffuse intravascular coagulation and induce thrombocytopenia by the consumption of the platelet.