Delayed alloimmunisation by random single donor platelet transfusions. A randomised study to compare single donor and multiple donor platelet transfusions in cancer patients with severe thrombocytopenia
Sintnicolaas, K.; Vriesendorp, H.M.; Sizoo, W.; Stenfert Kroese, W.F.; Haije, W.G.; Hop, W.C.; Abels, J.; Löwenberg, B.
Lancet 1(8223): 750-754
1981
ISSN/ISBN: 0140-6736 PMID: 6110956 Document Number: 182225
The effects of single-donor (SD) and multiple-donor (MD) platelet transfusions in 34 cancer patients with severe thrombocytopenia and hemorrhages were compared in a randomized study. Platelet recovery values in both groups were similar after the 1st transfusion. After the 2nd transfusion platelet recovery values were significantly better in those receiving SD transfusions. Platelet recovery values gradually declined with subsequent MD transfusions. Early alloimmunization in the MD transfused patients only was suggested. MD transfusion were estimted to be no longer effective after about 9 transfusions. Platelet recovery values were better indicators of early sensitization than was the lymphocytotoxicity test. Restriction of the number of donors per transfusion may postpone the development of refractoriness to random-donor platelet transfusions in thrombocytopenic patients.