Pros and cons of donor-specific blood transfusions in living related kidney transplantation
Sijpkens, Y.W.; Koep, L.J.; Persijn, G.G.; Van der Werf, B.A.
Netherlands Journal of Medicine 27(1): 1-5
1984
ISSN/ISBN: 0300-2977 PMID: 6231486 Document Number: 235080
From 1979 until 1981, 33 half-match high MLC living related donor-recipient pairs were selected for the donor-specific blood transfusion (DST) protocol. Three donor transfusions of fresh whole blood were given with 2-wk intervals. Of the 33 potential recipients, 15 (45%) developed a positive T cell cross-match or a persistent positive warm B cell cross-match to their blood donor, and transplantation was not performed. Eighteen patients (55%) had a negative cross-match and received a kidney from their blood donor. Fifteen (83%) of the 18 transplanted kidneys are at present functioning 3-30 mo. after transplantation. Graft survival and patient morbidity and mortality in the DST group are better than those in a historical control (non-DST) group.