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Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia

Kiefel, V.; Vicariot, M.; Breitfeld, C.; Giptner, A.; Schlüter, C.; Böhringer, M.; Santoso, S.; Kroll, H.; Mueller-Eckhardt, C.

Beitrage Zur Infusionstherapie und Transfusionsmedizin 32: 247-249

1994

ISSN/ISBN: 1023-2028
PMID: 9480101
Document Number: 426745
Neonatal alloimmune thrombocytopenia is the consequence of maternal alloimmunization against platelet-specific alloantigens, usually PIA1 or Br(a). The clinical picture is characterized by signs of haemorrhagic diathesis as a result of marked thrombocytopenia. In the last years, rare cases of immunization against 'low-frequency' or 'private' platelet alloantigens on the platelet glycoprotein (GP) complex IIb/IIIa have been found. This is the first report on NAIT due to maternal immunization against a low-frequency platelet alloantigen ('Iy') localized on platelet GP Ib/IX.

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