Structural and functional changes in the histohematic barrier of the rat myocardium in the postischemic period
Eskunov, P.N.; Semchenko, V.V.
Morfologiia 123(2): 60-64
2003
ISSN/ISBN: 1026-3543 PMID: 12891782 Document Number: 554548
The aim of this study was to examine the myocardial histohematic barriers during the rehabilitation period after a cardiac arrest for 10 min. The electron histochemical analysis was applied to evaluate the permeability of histohematic barriers, to assess their ultrastructure and calcium localization. During 24 hours post resuscitation the destructive and compensatory-adaptive changes were found in the microcirculatory bed, accompanied by a pericapillary space edema, selective elevation of sarcolemmal permeability and calcium redistribution in cardiomyocytes. The structural and functional disturbances of histohematic barriers following the total ischemia are important factors of myocardial reperfusion lesions and of cardiodepression.