The role of anti-dsDNA autoantibodies in the pathogenesis of atherosclerosis
Mastej, K.; Adamiec, R.
Przeglad Lekarski 60(11): 748-750
2003
ISSN/ISBN: 0033-2240 PMID: 15058049 Document Number: 552866
This paper presents involvement of autoimmune mechanism, and especially the role of autoantibodies anti-dsDNA (double stranded DNA) in atherosclerosis. Authors on the basis of results from experimental models and human studies demonstrate contribution of antibodies anti-DNA in the pathogenesis of atherosclerosis. Antibodies anti-dsDNA may play a role in atherosclerosis by promoting accumulation of cholesterol in macrophages and smooth muscle cells, influence on dyslipoproteinemias, cytotoxicity and releasing cytocines.