A case of allopurinol-induced muscular damage in a chronic renal failure patient
Terawaki, H.; Suzuki, T.; Yoshimura, K.; Hasegawa, T.; Takase, H.; Nemoto, T.; Hosoya, T.
Nihon Jinzo Gakkai Shi 44(1): 50-53
2002
ISSN/ISBN: 0385-2385 PMID: 11925947 Document Number: 551454
A 73-year-old woman with chronic renal failure developed generalized muscular weakness and pain 6 days after the start of allopurinol treatment(200 mg/day). Routine laboratory tests revealed elevated levels of serum creatine kinase, and the patient was clinically diagnosed as rhabdomyolysis, due probably to severe myositis. A high level of serum oxipurinol, the chief active metabolite of allopurinol, was also revealed. The muscular weakness was relieved in seven weeks with intermittent hemodiafiltration.