Top Abstract Purchase Related
Home
>
Node
>
Subnode

Anti-TA226 human monoclonal antibody (ACA-11) against glioma

Kokunai, T.

Nihon Rinsho. Japanese Journal of Clinical Medicine 60(1): 100-106

2002

ISSN/ISBN: 0047-1852
PMID: 11808318
Document Number: 551371
A human monoclonal antibody (ACA-11) against TA226 reacted with various glioma tissues, but did not react with normal brain tissues. TA226 was expressed on glioma cells and not detected in serum and cerebrospinal fluid. ACA-11 exhibited antibody-dependent cell cytotoxicity against glioma cells. Half life in serum concentration of ACA-11 in glioma patients was 75.33 hours. Phase II study of ACA-11 was performed against 111 cases of glioma. 1 mg of ACA-11 was administrated once or twice/week during 24 weeks. Overall response rate was 24.2% (16/66). Mild adverse reaction was found in 10 cases (9.2%). In conclusion, the specific immunotherapy using human monoclonal antibody, ACA-11, is safe and effective therapy in patients with glioma.

Document emailed within 1 workday
Secure & encrypted payments

Tsuji, T.; Kimura, Y.; Murakami, T.; Sasaki, K.; Shinozaki, F. 1990: An immunohistochemical evaluation of Warthin's tumor using the monoclonal anti-human lung adenocarcinoma antibody KM-93 and the anti-human gastric carcinoma antibody KM-231 Gan no Rinsho. Japan Journal of Cancer Clinics 36(7): 783-786
van der Heijden, R.W.; Bunschoten, H.; Pascual, V.; Uytdehaag, F.G.; Osterhaus, D.M.; Capra, J.D. 1990: Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal idiotypic antibody reveals extensive somatic variability suggestive of an antigen-driven immune response Journal of Immunology 144(7): 2835-2839
Cope, D.A.; Dewhirst, M.W.; Friedman, H.S.; Bigner, D.D.; Zalutsky, M.R. 1990: Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia Cancer Research 50(6): 1803-1809
Sawada, T.; Hashimoto, S. 2007: Human monoclonal antibody to B-lymphocyte stimulator (belimumab) and humanized anti-LFA-1 monoclonal antibodies (efalizumab) Nihon Rinsho. Japanese Journal of Clinical Medicine 65(7): 1239-1242
Chakraborty, M.; Mukerjee, S.; Foon, K.A.; Köhler, H.; Ceriani, R.L.; Bhattacharya-Chatterjee, M. 1995: Induction of human breast cancer-specific antibody responses in cynomolgus monkeys by a murine monoclonal anti-idiotype antibody Cancer Research 55(7): 1525-1530
Chattopadhyay, P.; Kaveri, S.V.; Byars, N.; Starkey, J.; Ferrone, S.; Raychaudhuri, S. 1991: Human high molecular weight-melanoma associated antigen mimicry by an anti-idiotypic antibody: characterization of the immunogenicity and the immune response to the mouse monoclonal antibody IMel-1 Cancer Research 51(22): 6045-6051
Blancher, A.P.; Reid, M.E.; Alié-Daram, S.J.; Dugoujon, J.M.; Roubinet, F.L. 1996: Characterization of human anti-hrB-like monoclonal antibody Immunohematology 12(3): 119-122
Blottière, H.M.; Douillard, J.Y.; Koprowski, H.; Steplewski, Z. 1990: Immunoglobulin class and immunoglobulin G subclass analysis of human anti-mouse antibody response during monoclonal antibody treatment of cancer patients Cancer Research 50(3 Suppl): 1051s-1054s
Tuch, B.E.; Beretov, J.; Mandel, T.E.; Koulmanda, M. 1995: Effect of anti-CD4 monoclonal antibody on survival of xenografted human fetal pancreas Transplantation Proceedings 27(3): 2183-2184
Lewis, A.P.; Lemon, S.M.; Barber, K.A.; Murphy, P.; Parry, N.R.; Peakman, T.C.; Sims, M.J.; Worden, J.; Crowe, J.S. 1993: Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody Journal of Immunology 151(5): 2829-2838
Chen, J.; Zhang, Y.; Chu, Y. 1998: Inhibition of human stomach cancer metastasis in vivo by anti-P-selectin monoclonal antibody Zhonghua Yi Xue Za Zhi 78(6): 437-439
Daifuku, R.; Panacek, E.A.; Haenftling, K.; Swenson, W.K.; Prescott, A.W.; Johnson, J.L. 1993: Pilot study of anti-lipopolysaccharide human monoclonal antibody MAB-T88 in patients with gram-negative sepsis Human Antibodies and Hybridomas 4(1): 36-39
Gazitt, Y.; Or, R.; Mumcuoglu, M.; Slavin, S. 1987: Monoclonal rat anti-human lymphocyte antibody Campath-1 binds to T and B lymphocytes but effectively lyses only T cells Bone Marrow Transplantation 2(4): 427-433
Konno, H.; Suzuki, H.; Tadakuma, T.; Kumai, K.; Yasuda, T.; Kubota, T.; Ohta, S.; Nagaike, K.; Hosokawa, S.; Ishibiki, K. 1987: Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein monoclonal antibody Cancer Research 47(16): 4471-4477
Perosa, F.; Scudeletti, M.; Imro, M.A.; Dammacco, F.; Luccarelli, G.; Indiveri, F. 1997: Anti-CD4 monoclonal antibody (mAb) and anti-idiotypic mAb to anti-CD4 in the therapy of autoimmune diseases Clinical and Experimental Rheumatology 15(2): 201-210
Ruud, E.; Kindberg, G.M.; Blomhoff, H.K.; Godal, T.; Berg, T. 1988: Degradation of a monoclonal anti-mu chain antibody in a human surface IgM-positive B cell line starts in prelysosomal vesicle Journal of Immunology 141(9): 2951-2958
Moroz, C.; Zaspin, E.; Shohat, B. 1996: An immunosuppressive effect of anti-p43 monoclonal antibody on human xenogeneic graft versus host response is mediated by CD8+ T cells Transplantation Proceedings 28(6): 3196-3198
Quinn, A.; Adderson, E.E.; Shackelford, P.G.; Carroll, W.L.; Cunningham, M.W. 1995: Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes Journal of Immunology 154(8): 4203-4212
Bemelmans, M.H.; Abramowicz, D.; Gouma, D.J.; Goldman, M.; Buurman, W.A. 1994: In vivo T cell activation by anti-CD3 monoclonal antibody induces soluble TNF receptor release in mice. Effects of pentoxifylline, methylprednisolone, anti-TNF, and anti-IFN-gamma antibodies Journal of Immunology 153(2): 499-506
Suzuki, H. 1991: Experimental studies on targeting chemotherapy using adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein monoclonal antibody Nihon Geka Gakkai Zasshi 92(3): 257-265