Polymorphism of the tumor necrosis factor alpha gene in patients with infiltrative tuberculosis and from the Bashkorstan populations

Bikmaeva, A.R.; Sibiriak, S.V.; Valiakhmetova, D.Kh.; Khusnutdinova, E.K.

Molekuliarnaia Biologiia 36(5): 784-787

2002


ISSN/ISBN: 0026-8984
PMID: 12391840
Document Number: 551200
The polymorphism at position -308 of the TNF-alpha gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (chi2=11.69, p=0.001), suggesting an association of this allele with higher risk of pulmonary tuberculosis or a disturbed immune response.

Document emailed within 1 workday
Secure & encrypted payments