Molecular conformation of substances with antimuscarinic activity
Del Pra, A.; Mammi, M.; Valle, G.; Pratesi, P.; Villa, L.
Il Farmaco; Edizione Scientifica 28(9): 675-680
1973
ISSN/ISBN: 0430-0920 PMID: 4749853 Document Number: 5507
The solid state conformation of the 3,3-diphenylpropyltrimethylammonium iodide, a substance endowed with atropine-like activity, has been studied by X-Rays and compared with that of other antagonists of acetylcholine at muscarinic level. It is relevant that in all the molecules taken into consideration, there is a phenyl group at a fixed distance of about 6 A from the quaternary nitrogen. This conclusion supports the idea that the accessory receptor areas possess, at least in the case of the muscarine receptor, well localized reactive sites for the antagonist molecule.
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