Peptide-protein complexes of angiotensins in the mechanisms of thirst
Kotov, A.V.; Tolpygo, S.M.; Pevtsova, E.I.; Obukhova, M.F.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 88(6): 686-698
2002
ISSN/ISBN: 0869-8139 PMID: 12154565 Document Number: 549459
The comparative analysis of learned and natural drinking behavior under native angiotensin-I (A-I), angiotensin-II (A-II) and its protein-peptides complexes (PPC) administration in rats, was performed. Various effects of these substances on drinking behavior were observed. PPC of A-I became a dipsogenic agent as compared with the native one. Moreover, PPC of A-II facilitated selectively learned and not natural forms of drinking behavior. It's suggested that PPC of angiotensins play a specific role in endogenous mechanisms of thirst. An important function of this complexes due to their conformational properties and participation in realization of basic needs, is discussed.