Examining the distribution of HLA antigens in patients with tuberculosis and in healthy individuals in the Erza District, Republic of Tyva
Matrashkin, A.G.; Mes'ko, E.M.; Pospelov, L.E.; Eremeev, V.V.; Khaĭby, S.B.; Chistiakova, N.I.
Problemy Tuberkuleza 12: 15-16
2002
ISSN/ISBN: 0032-9533 PMID: 12611327 Document Number: 548307
The paper presents the results of typing by HLA classes I and II antigens in 55 patients with tuberculosis and 85 healthy Tyvians in the Erza District. Republic of Tyva. HLA I and II antigens were determined serologically and polymerase chain reaction, respectively. Tyvian patients with pulmonary tuberculosis had HLA B7 antigen more frequently and HLA B12 antigen less frequently than the controls. The findings suggest that pulmonary tuberculosis is associated with HLA-DRB1 14(6) specificity in this district of the Republic of Tyva. These data may be useful in forming groups at risk for pulmonary tuberculosis in the district under study.