V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?
Golub, R.
Archivum Immunologiae et Therapiae Experimentalis 50(4): 255-262
2002
ISSN/ISBN: 0004-069X PMID: 12371621 Document Number: 548218
Lymphocytes can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.
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