Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations
Caligiuri, M.A.; Schichman, S.A.; Strout, M.P.; Mrózek, K.; Baer, M.R.; Frankel, S.R.; Barcos, M.; Herzig, G.P.; Croce, C.M.; Bloomfield, C.D.
Cancer Research 54(2): 370-373
1994
ISSN/ISBN: 0008-5472 PMID: 8275471 Document Number: 423999
Translocations which involve chromosome band 11q23 are frequently found in infants and adults with acute myeloid leukemia (AML) or acute lymphoblastic leukemia. We previously cloned a gene called ALL-1 which spans the 11q23 breakpoint and is rearranged in most cases of leukemia with 11q23 abnormalities. In the present report, we have investigated the occurrence of ALL-1 rearrangement in cases of AML without cytogenetic evidence of 11q23 abnormalities. We detected molecular rearrangements of the ALL-1 gene in 3 of 4 patients with de novo AML and trisomy 11 as a sole chromosomal abnormality. Furthermore, we found DNA rearrangements of ALL-1 in 2 of 19 patients with de novo AML and normal cytogenetics. We conclude that molecular rearrangement of ALL-1 often can be detected in de novo AMI, despite the absence of cytogenetic abnormalities involving 11q23.