Chromosomal translocation t(14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin&apos;s lymphoma and chronic lymphocytic leukemia: a molecular genetic analysis of 176 cases

Van Krieken, J.H.; McKeithan, T.W.; Raghoebier, S.; Medeiros, L.J.; Kluin, P.M.; Raffeld, M.; Van Krieken, J.H; McKeithan, T.W; Raghoebier, S; Medeiros, L.J; Kluin, P.M; Raffeld, M

Home

>

Node

>

Subnode

Chromosomal translocation t (14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin's lymphoma and chronic lymphocytic leukemia: a molecular genetic analysis of 176 cases

Van Krieken, J.H.; McKeithan, T.W.; Raghoebier, S.; Medeiros, L.J.; Kluin, P.M.; Raffeld, M.

Leukemia 4(12): 811-812

1990

ISSN/ISBN: 0887-6924

PMID: 2243504

Document Number: 356103

Using a probe for the newly described bcl-3 gene near the breakpoint of the t(14;19), 176 cases of non-Hodgkin lymphoma and B cell chronic lymphocytic leukemia were analyzed. Rearrangement of the bcl-3 gene was found in only one case; a follicular lymphoma involving the salivary gland that had progressed to a diffuse large cell lymphoma. We conclude that rearrangement of the bcl-3 gene as detected by our method occurs rarely in mature B or T cell neoplasms.