Synthesis of a new cyclodextrin derivative and its application as CGC chiral stationary phase in determination of enantiomeric excess
Shi, X.-y.; Guo, H.-c.; Wang, M.; Jin, W.-g.; Zhou, J.-m.
Se Pu 20(1): 34-36
2002
ISSN/ISBN: 1000-8713 PMID: 12541614 Document Number: 547771
A new cyclodextrin (CD) derivative, 2,6-di-O-benzyl-3-O-valeryl-beta-CD, was synthesized and characterized by 1H NMR and IR. Using the beta-CD derivative as chiral stationary phase of capillary gas chromatography, one chiral column was prepared. On this column, the enantiomeric excesses (e.e.) of 1-(2,4-dichlorophenyl) ethanol obtained by asymmetric catalytic hydrogenation of 2,4-dichloroacetophone and trans-3-propyloxiranemethanol synthesized by Sharpless epoxidation of trans-2-hexenol were determined and the catalytic reactions were evaluated. The results are satisfactory.