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Direct enantiomeric separation of mianserin and 6-azamianserin derivatives using chiral stationary phases

Selditz, U.; Liao, Y.; Franke, J.P.; de Zeeuw, R.A.; Wikström, H.

Journal of Chromatography A 803(1-2): 169-177

1998

ISSN/ISBN: 0021-9673
PMID: 9634278
Document Number: 494001
The direct enantiomeric separation of mianserin and 6-azamianserin and some of their derivatives, respectively, by means of HPLC using two different chiral selectors was investigated. For the cellulose-based Chiralcel OD column, a strong dependence of the lipophilicity of the compounds tested on the retention behaviour was observed. To some extent, this was also found for the enantiomeric separation on the amylose-based Chiralpak AD column. In some cases a complementary behaviour of these two phases was observed: racemic mixtures that could not be separated by one column could be resolved by the other one.

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