Preparation and application of a novel Pirkle-type chiral stationary phase in liquid chromatography
Zhang, D.; Li, F.; Hyun, M.H.
Die Pharmazie 62(4): 258-261
2007
ISSN/ISBN: 0031-7144 PMID: 17484279 Document Number: 609127
A new high-performance liquid chromatographic Pirkle-type chiral stationary phase (CSP) was prepared starting from R-(+)-1,1'-binaphthyl-2,2'-diamine. The CSP prepared was successfully applied in resolving various N-(3,5-dinitrobenzoyl)-alpha-amino amides and N-acyl-1-aryl-1-aminoalkanes and found to be effective. The chiral recognition mechanism was proposed to be pi-pi interaction and simultaneously hydrogen bonding interactions between the CSP and the analytes.