HLA-B35 association with nephritis in Henoch-Schönlein purpura
Amoli, M.M.; Thomson, W.; Hajeer, A.H.; Calviño, M.C.; Garcia-Porrua, C.; Ollier, W.E.R.; Gonzalez-Gay, M.A.
Journal of Rheumatology 29(5): 948-949
2002
ISSN/ISBN: 0315-162X PMID: 12022355 Document Number: 544157
Objective: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schonlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. Methods: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. Results: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. Conclusion: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.