Detection method for platelet activation markers
Satoh, K.; Yatomi, Y.; Ozaki, Y.
Rinsho Byori. Japanese Journal of Clinical Pathology 50(8): 773-778
2002
ISSN/ISBN: 0047-1860 PMID: 12373813 Document Number: 542782
The assessment of platelet activation levels may be useful for identifying patients who would benefit from antiplatelet therapy and prediction of ischemic events. Laboratory markers of platelet activation include activation-dependent changes in glycoprotein (GP) IIb/IIIa complex, exposure of granule membrane proteins, binding of secreted platelet proteins, and development of procoagulant surfaces. Whole blood flow cytometry is a popular and useful method for the detection of these markers of platelet activation. Monoclonal antibodies against platelet surface glycoproteins are used to identify activated platelets.