Investigation of the mechanisms of platelet activation mediated through adrenoceptors
Gabrielian, E.S.; Akopov, S.E.; Ayvasian, A.G.
Acta Physiologica et Pharmacologica Bulgarica 17(4): 3-7
1991
ISSN/ISBN: 0323-9950 PMID: 1841515 Document Number: 384142
ADP induced membrane reorganization leading to an increase in membrane microviscosity with the decrease in the distance between protein globules and membrane surface. Adrenaline at low concentrations enhanced the ADP-induced platelet aggregation and deepened the structural reorganization. Analogous phenomenon was induced by the selective alpha 2-adrenoceptor agonist azopexole. The selective alpha 2-adrenoceptor antagonist idazoxan eliminated the effects of both adrenaline and azopexole. It is suggested that alpha 2-adrenoceptor activation leads to an increase in the number of fibrinogen receptors on platelet membranes due to the more pronounced advancement of membrane proteins to the membrane surface.