Investigation of Platelet Adhesiveness in Patients With Coronary Artery Disease and Acute Myocardial Infarction Using the Platelet Adhesion Assay (PADA)
Walter, T.; Szabo, S.; Kazmaier, S.; Suselbeck, T.; Götz Nowak; Borggrefe, M.; Hoffmeister, H.M.; Dempfle, C.E.
Clinical Laboratory 57(5-6): 315-320
2011
ISSN/ISBN: 1433-6510 PMID: 21755820 Document Number: 13232
Background: Increased platelet reactivity may contribute to the development of coronary artery disease and myocardial infarction. The aim of the present study was to assess platelet adhesiveness in different stages of coronary artery disease using the platelet adhesion assay (PADA). In addition, the acute effect of coronary angiography and stent implantation on platelet adhesiveness was examined. Methods: 85 patients with stable coronary artery disease (SAP - stable angina pectoris) and 19 patients with acute myocardial infarction (AMI) were enrolled in the study. 35 volunteers served as controls. Blood sampling in SAP and AMI patients was done before coronary angiography to measure the adhesion index (AI) using the PADA. In 33 patients additional blood was drawn at the end of coronary angiography. In 6 patients blood samples were drawn also after stent implantation. Results: In blood samples from patients with an AMI the AI was significantly higher than in blood samples from the SAP group (p Conclusions: This is the first study to show that PADA, a quick and simple laboratory method for the quantitative determination of platelet adhesiveness, is able to detect platelet hyper-adhesiveness in patients with AMI.
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