Cytomegalovirus infection associated with plasma endothelin and P-selectin in patients with essential hypertension
Feng, T.; Yuan, H.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 15(4): 377-379
2001
ISSN/ISBN: 1003-9279 PMID: 11986733 Document Number: 540366
To investigate the relationship between human cytomegalovirus (HCMV) infection and plasma endothelin and P-selectin in patients with essential hypertension. Blood samples of 98 patients with essential hypertension were collected for HCMV IgM and IgG antibodies, plasma endothelin and plasma P-selectin by chemiluminescence technique, radio-immunoassay and ELISA. The rates of positive HCMV IgM antibodies and positive rates for both HCMV IgM and IgG antibodies were 56.12% and 54.08%, respectively, which were higher than that of the control group (P=0.05). The level of plasma endothelin and P-selectin in patients with positive HCMV IgM antibodies was 95.53 +/- 5.06 ng/ml and 42.50 +/- 3.28 ng/ml, respectively, which were higher than that in patients with negative HCMV IgM antibodies (71.60 +/- 4.34 ng/ml and 27.41 +/- 5.28 ng/ml) and that of the control group (48.77 +/- 5.96 ng/ml and 19.80 +/- 4.62 ng/ml). These results suggest that HCMV active infection may aggravate vascular endothelium lesi on in patients with essential hypertension and contribute to the increase of endothelin and P-selectin.