Effect of various antihypertensive drugs on plasma fibrinogen levels in patients with essential hypertension
Bhatia, J.; Mahajan, P.; Sikka, M.; Kalra, O.P.
Indian Journal of Medical Sciences 55(9): 491-494
2001
ISSN/ISBN: 0019-5359 PMID: 11887299 Document Number: 539206
In recent years, substantial evidence has accumulated to unambiguously implicate high plasma fibrinogen levels as a major cardiovascular risk factor. An open prospective and randomised pilot study was therefore undertaken in mild to moderate hypertensives to evaluate the effect of various antihypertensive drugs viz enalapril, felodipine and prazosin on the blood pressure and plasma fibrinogen levels. The systolic and diastolic blood pressures were determined at 0, 4 and 8 weeks whereas plasma fibrinogen assays were done at baseline and at the end of the 8th week of treatment in all the drug-treated groups. It was observed that although all the three drugs effectively controlled blood pressure, only enalapril significantly reduced plasma fibrinogen levels. Due to this additional effect, enalapril has potential to control two major cardiovascular risk factors--hypertension and high plasma fibrinogen levels--simultaneously.