Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin
Doihara, H.; Yoshitomi, S.; Hino, M.; Teramoto, A.; Ishibe, Y.; Ogasawara, Y.; Nagahiro, I.; Sano, Y.; Shimizu, N.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(2): 229-233
2001
ISSN/ISBN: 0385-0684 PMID: 11242652 Document Number: 540035
Two cases of advanced and metastatic breast cancers were treated by docetaxel (TXT) in combination with intra-arterial infusion of adriamycin (ADM). Patients received 60 mg/body TXT i.v. and 30 mg/body ADM ia (AT therapy) bi-weekly. Clinical responses were observed in these two patients and the durations of responses were over 20 weeks. Critical toxicities of grade 2 leukopenia and alopecia were observed but grade 4 severe toxicities were not. Thus AT therapy can be easily and safely performed with outpatients. This therapy can improve the response rate and time to progression; therefore phase I or phase I/II clinical trials of AT therapy in Japan are recommended.