Transfusion transmitted virus infection in mother-to-infant transmission
Zhong, M.; Wen, S.; Zhou, F.
Zhonghua Fu Chan Ke Za Zhi 36(6): 328-329
2001
ISSN/ISBN: 0529-567X PMID: 11783126 Document Number: 539780
To investigate the perinatal infection of transfusion transmitted virus (TTV) in the mother-to-infant transmission and molecular evidence. TTV was examined in serum from 104 mothers and umbilical blood of their infants by a semi-nested polymerase chain reaction technique. TTV nucleotide sequences isolated from two sets of mother/infant pairs were analyzed. The TTV detection rate was 13.46% (15/104), and it was 4.81% (5/104) in the umbilical blood of their newborns. Homology analysis was done by sequencing between positions 1,915 and 2,185 of the published TTV genome, Analysis of TTV sequences from the 2 pairs of mother and infant both infected confirmed a genetic link between the virus of the infected mother and their infected infants. There is a possibility of vertical maternal-fetal transmission of TTV.