Need for review of prevention of mother-to-child transmission practice especially in discordant couples: a case of mother-to-child transmission of HIV during breast feeding by a mother who tested HIV negative antenatally
Musiime, V.; Ssali, F.; Kizito, H.; Kityo, C.; Mugyenyi, P.
Aids 21(12): 1658-1659
2007
ISSN/ISBN: 0269-9370 PMID: 17630569 DOI: 10.1097/qad.0b013e32826fb7d8Document Number: 282701
In the TORO, RESIST and POWER trials, the HIV-RNA < 50 copy endpoint showed the strongest durability over time, whereas HIV-RNA reductions of more than 1 log10 or below 400 copies/ml were less sustained during 48 weeks of treatment. Clinical trials of new antiretroviral drugs in highly experienced patients also show high rates of HIV-RNA suppression below 50 copies/ml. HIV-RNA suppression below 50 copies/ml should now become the standard efficacy endpoint across trials of both naive and experienced patients.
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