Hypothalamic releasing factor in primary and situational depression
Dekeyser, Y.F.
International Journal of Neurology 14(2-4): 269-272
1980
ISSN/ISBN: 0020-7446 PMID: 6764642 Document Number: 5397
The author presents his first successfully treated depressed patients with LH-RH (HRF Ayerst) out of a series of doubleblind placebo controlled cross-overed study in progress. Evaluation has been based on repeated psichiatric examinations including the objective Zung and Hamilton ratings. Emphasis is given in discussing his findings with those already reported in the literature and the differences in the rapidity of responses to HRF in primary and stressed associated depression. In the latter. response is observed earlier with symptomatic improvements within hours. in the former however the subjective as well as the objeclive responses is delayed and requires several injections. No correlation could be established het cell the degree of response znul the size of dosage. The determining factor seems to he the frequency of dosing in both types of depression
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