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Activation of mu-opioid receptors and cardiomyocyte resistance to free radical damage

Lasukova, T.V.; Rebrova, T.I.

Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 2: 15-17

2001

ISSN/ISBN: 0031-2991
PMID: 11550361
Document Number: 538472
It has been found that after intravenous administration of selective agonist of mu-opioid receptors DAGO (0.1 mg/kg 15 min before heart excision) isolated rat heart becomes resistant to ischemia (45 min) and reperfusion (60 min) ex vivo. The in vivo pretreatment with DAGO prevented reperfusion injury of cardiac cells and decreased myocardial content of conjugated dienes during ischemia and reperfusion of the heart in vitro. In addition, similar mu-opioid receptor stimulation promotes a postischemic recovery of myocardial contractility in the postischemic period. However, this receptor activation does not affect heart tolerance to free radical damage during perfusion of isolated heart by a solution containing Fe(2+)-ascorbic acid.

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Lishmanov, I.B.; Maslov, L.N.; Gross, G.G. 2007: Activation of opioid receptors changes heart resistance to an arrhythmogenic action of ischemia and reperfusion Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 17(2): 21-26
Parsons, C.G.; Herz, A. 1990: Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress Journal of Pharmacology and Experimental Therapeutics 255(2): 795-802
Simadibrata, M. 2011: Anti-free radical effects of dark chocolate in radical damage and constipation Acta Medica Indonesiana 43(4): 217
Saprin, A.N.; Kalinina, E.V.; Serezhenkov, V.A.; Kotova, I.N.; Solomka, V.S.; Shcherbak, N.P. 2006: Changes in the free-radical state and level of free iron during the formation of drug resistance in tumor cells Biofizika 51(3): 485-490
Obut, T.A.; Saryg, S.K.; Grigor'eva, T.A.; Dement'eva, T.I. 2008: The denydroepiandrosterone sulfate thyroid activation through the mu-opioid receptors under cold influences Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 94(12): 1420-1425
Dement'eva, I.I.; Andrianova, M.I.; Paliulina, M.V.; Kukaeva, E.A.; Mil'chakov, V.I.; Charnyĭ, I.S. 2001: Free radical damage in the transplanted liver Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 23-25
Mukhin, V.N.; Abdurasulova, I.N.; Pavlov, K.I.; Klimenko, V.M. 2015: Effects of activation of kappa-opioid receptors on the behavior at the postnatal development of the stress reactivity systems Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 101(3): 268-278
Levytskyĭ, E.L.; Gubskyĭ, I.Y. 1994: Free radical damage of the nuclear genetic apparatus of cells Ukrainskii Biokhimicheskii Zhurnal 66(4): 18-30
Suarez-Roca, H.; Maixner, W. 1993: Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices Journal of Pharmacology and Experimental Therapeutics 264(2): 648-653
Chaialo, P.P.; Pliushch, G.I. 2001: Pathogenic role of free-radical damage in radiation-induced atherosclerosis Fiziolohichnyi Zhurnal 47(1): 107-115
Schneider, J.E.; Browning, M.M.; Zhu, X.; Eneff, K.L.; Floyd, R.A. 1989: Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA Mutation Research 214(1): 23-31
Gushchin, I.S.; Tsynkalovskiĭ, O.R. 1990: Free radical system and activation of allergy target cells Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 6: 3-10
Rui, F.; Zhou, J-fu.; Shao, J-min.; Zhang, X-ying.; He, J-fei. 2004: Relationship between acute dipterex poisoning and oxidative stress and free radical damage Zhonghua Yu Fang Yi Xue Za Zhi 38(6): 419-421
Xu, Y.B.; Zhu, J.S.; Zhang, G.P. 1994: Activation and free radical formation of leukocytes in patients with acute ischemic stroke Zhonghua Nei Ke Za Zhi 33(12): 799-802
Hosler, B.A.; Brown, R.H. 1995: Copper/zinc superoxide dismutase mutations and free radical damage in amyotrophic lateral sclerosis Advances in Neurology 68: 41-46
Stewart, P.E.; Hammond, D.L. 1994: Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat Journal of Pharmacology and Experimental Therapeutics 268(2): 701-708
Southard, J.H.; Marsh, D.C.; McAnulty, J.F.; Belzer, F.O. 1987: Oxygen-derived free radical damage in organ preservation: activity of superoxide dismutase and xanthine oxidase Surgery 101(5): 566-570
Marastoni, M.; Salvadori, S.; Tomatis, R.; Borea, P.A.; Bertelli, G. 1987: Opioid peptides. Biological study of [D-MetO2] dermorphin analogues in relation to the plurality of opioid receptors. Xi Il Farmaco; Edizione Scientifica 42(2): 125-131
Ray, S.B.; Gupta, Y.K.; Wadhwa, S. 2005: Expression of opioid receptor-like 1 (ORL1) and mu opioid receptors in the spinal cord of morphine tolerant mice Indian Journal of Medical Research 121(3): 194-202
Sultana, S.; Saleem, M.; Sharma, S.; Khan, N. 2003: Lupeol, a triterpene, prevents free radical mediated macromolecular damage and alleviates benzoyl peroxide induced biochemical alterations in murine skin Indian Journal of Experimental Biology 41(8): 827-831