Activation and free radical formation of leukocytes in patients with acute ischemic stroke
Xu, Y.B.; Zhu, J.S.; Zhang, G.P.
Zhonghua Nei Ke Za Zhi 33(12): 799-802
1994
ISSN/ISBN: 0578-1426 PMID: 7768134 Document Number: 438817
The leukocyte count, leukocyte activation, lipoperoxidant (Lpo) of leukocytes and C3 in the peripheral blood were determined in 44 patients with acute ischemic stroke and the results were compared with those in age-matched healthy controls. No significant difference in mean leukocyte counts was observed between the patients and controls. The levels of leukocyte activation in the patients were significantly higher than those in the controls (137.94 +/- 38.86 U/L vs 92.22 +/- 20.29 U/L, P < 0.01), while the levels of Lpo of leukocytes and C3 were significantly lower than those in the controls (0.90 +/- 0.87 mumol/L and 0.96 +/- 0.72 g/L vs 1.57 +/- 1.29 mumol/L and 1.69 +/- 0.70 g/L, P < 0.01). The changes of these levels were in correlation with the extent of cerebral infarction. It is suggested that leukocytes might be involved in the pathophysiological process of acute ischemic brain damage. Its mechanisms and route of activation were discussed briefly.