Experimental amoebic liver abcess produced by oral administration of Entamoeba histolytica cysts
Sadaka, H.A.; El-Nassery, S.M.; Allam, S.R.; Eissa, M.M.; Baddour, N.M.
Journal of the Egyptian Society of Parasitology 31(2): 407-417
2001
ISSN/ISBN: 1110-0583 PMID: 11478441 Document Number: 537383
This study aims to determine the possibility of amoebic invasion and liver abscess formation following oral administration of E. histolytica cysts in Swiss albino mice. Parasitological and histopathological changes in mice colon and liver tissues were sequentially followed. Three weeks postinfection (p.i.), 5% of immunocompetent and all cortisonized immunosuppressed mice passed the parasite in their faeces. Only 70% of the latter group of mice sacrificed at that time developed invasive intestinal amoebiasis. At the end of the experiment (12 weeks p.i.), all of the remaining immunosuppressed animals developed the same intestinal pathology. Amoebic liver abscess was detected in 62.5% of them. Oral inoculation of E. histolytica cysts constitutes an easy highly reproducible procedure for inducing liver abscess in immunosuppressed mice.