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Inhibition of invasion and multiplication of Toxoplasma gondii in human colonic epithelial cells by a monoclonal antibody against protein SAG2

Osorio, J.C.; Sánchez, R.M.; Iraola, R.C.; Pérez, J.S.

Revista Cubana de Medicina Tropical 53(3): 161-169

2001

ISSN/ISBN: 0375-0760
PMID: 15846919
Document Number: 536686
By an bromodeoxyuridine (BrdU) incorporation assay, it was proved hat an IgG 1 subclass, murine monoclonal antibody to surface protein SAG2 of Toxoplasma gondii is capable of reducing the invasion and multiplication of the parasites in highly differentiated mucine secretory HT29-18N2 line cells from a human colon adenocarcinoma. This result shows the importance of surface protein SAG2 of T.gondii in invasion and further multiplication of parasites in the host cell.

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